Abstract #2321

Lactate chemical exchange saturation transfer MRI as a biomarker for differentiating lactate dehydrogenase activity in 9L and F98 glioma

Puneet Bagga¹, Mohammad Haris^2,3, Hari Hariharan¹, and Ravinder Reddy¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Research Branch, Sidra Medicine, Doha, Qatar, ³Laboratory Animal research Center, Qatar University, Doha, Qatar

Lactate chemical exchange saturation transfer (LATEST) MRI method has been shown to be applicable in detecting and imaging changes in the lactate level in human subjects post heavy exercise and to measure the lactate in a mouse model of lymphoma. In this study, LATEST was implemented to differentiate the lactate dehydrogenase (LDH) activity in vivo in two different preclinical glioma models. The two gliomas studied are widely used 9L (highly immunogenic, gliosarcoma) and F98 (weakly immunogenic, glioblastoma). The LATEST contrast was found to be higher in the tumor region of F98 rats compared to the 9L glioma carrying rats.

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