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Abstract #2329

Baseline Tumor Apparent Diffusion Coefficient Value Can Predict First-line Sunitinib Therapy Response of Stage IV Clear Cell Renal Cell Carcinoma

Liqiang Cui1, Yichen Wang2, and Yan Chen2

1Surgery, Peking Union Medical College Hospitall, Chinese Academy of Medical Sciences, Beijing, China, 2National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Our single-center retrospective study focused on Stage IV Clear Cell Renal Cell Carcinoma patients who received first-line sunitinib therapy and found that baseline tumor apparent diffusion coefficient value derived from 3T diffusion weighted imaging showed different level in different response group. Baseline tumor ADC value also had significant correlation with progression-free survival. Patients with higher tumor ADC value had significantly longer progression-free survival. Basline tumor ADC can be a potential predictor in assessing targeted therapy response of Stage IV ccRCC.

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