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Abstract #2330

Treatment response and recurrence prediction on MR during radiotherapy in patients with head and neck squamous cell carcinoma

Tim Schakel1, Boris Peltenburg1, Remco de Bree2, Chris H.J. Terhaard1, and Marielle E.P. Philippens1

1Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, 2Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands

Weekly MR imaging allows for tumor monitoring during treatment. T2 weighted imaging and distortion-free DW-TSE SPLICE were acquired weekly in 20 patients. Changes in volume and ADC could be followed over the course of (chemo)radiotherapy: volume decreases and ADC increases. Tumor delineation is crucial and becomes increasingly difficult during treatment. For the current patient population, 4 patients developed recurrent disease. However, volume changes measured on T2 weighted imaging and ADC changes did not yet show to be prognostic of tumor recurrence.

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