Abstract #2337

Response monitoring by DCE-MRI in an experimental prostate tumor after single dose 12C-ion and photon radiotherapy

Alina Leandra Bendinger^1,2, Lisa Seyler³, Maria Saager^4,5, Charlotte Debus^5,6,7, Peter Peschke^4,5, Dorde Komljenovic¹, Jürgen Debus^5,7,8, Jörg Peter¹, Ralf Omar Floca^5,9, Christian Peter Karger^4,5, and Christin Glowa^4,5,7

¹Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany, ³Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen, Erlangen, Germany, ⁴Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ⁶Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁷Department of Radiation Oncology and Radiotherapy, University Hospital Heidelberg, Heidelberg, Germany, ⁸Clinical Cooperation Unit Radiation Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁹Department of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany

A series of DCE-MRI measurements was used to quantify the vascular changes after therapeutic and subtherapeutic doses of photon and ¹²C-ion irradiation of the anaplastic rat prostate tumor Dunning R3327-AT1. DCE-MRI data were analyzed by pharmacokinetic modelling employing the Extended Tofts model. Independent of dose, ¹²C-ions led to stronger and earlier treatment response than photons within the observation period indicated by increased K_trans and v_eparameters. Results were correlated to histological analyses for microvascular density, vessel maturity, tumor hypoxia, and proliferation that further underlined the faster, stronger, and more homogeneous treatment response after ^12C-ion irradiation.

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