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Abstract #2337

Response monitoring by DCE-MRI in an experimental prostate tumor after single dose 12C-ion and photon radiotherapy

Alina Leandra Bendinger1,2, Lisa Seyler3, Maria Saager4,5, Charlotte Debus5,6,7, Peter Peschke4,5, Dorde Komljenovic1, Jürgen Debus5,7,8, Jörg Peter1, Ralf Omar Floca5,9, Christian Peter Karger4,5, and Christin Glowa4,5,7

1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen, Erlangen, Germany, 4Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, 6Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, 7Department of Radiation Oncology and Radiotherapy, University Hospital Heidelberg, Heidelberg, Germany, 8Clinical Cooperation Unit Radiation Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany, 9Department of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany

A series of DCE-MRI measurements was used to quantify the vascular changes after therapeutic and subtherapeutic doses of photon and 12C-ion irradiation of the anaplastic rat prostate tumor Dunning R3327-AT1. DCE-MRI data were analyzed by pharmacokinetic modelling employing the Extended Tofts model. Independent of dose, 12C-ions led to stronger and earlier treatment response than photons within the observation period indicated by increased Ktrans and ve parameters. Results were correlated to histological analyses for microvascular density, vessel maturity, tumor hypoxia, and proliferation that further underlined the faster, stronger, and more homogeneous treatment response after 12C-ion irradiation.

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