Abstract #2343

Diffusion-weighted MRI for assessing longitudinal effect of radiation (photon beam) versus proton beam therapy on cranial bone marrow in children treated for brain tumors

Erika Pace^1,2, Enrico Clarke³, Henry Mandeville^3,4, Andrew Mackinnon^2,5, and Nandita M deSouza^1,2

¹Cancer Research UK Imaging Centre, The Institute of Cancer Research, Sutton, United Kingdom, ²MRI Unit, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom, ³Dept. of Clinical Oncology, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom, ⁴Children's and Young Person's Unit and Haemato-oncology Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, ⁵Department of Neuroradiology, Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom

Bone marrow ADC measurements were feasible from the clivus in children. Measurements were reproducible (95% confidence intervals -5.5% to +11%). Following radiation (photon) treatment or proton beam therapy, there was an early rise in ADC at 2 months consistent with bone marrow edema, followed by a fall. The level of early ADC increase (39% for radiation therapy, 42% for proton beam therapy) and pattern of change was similar in both treatment regimens.

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