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Abstract #2349

An analysis of post-processing steps for residue function dependent DSC-MRI biomarkers through their clinical impact on glioma diagnosis for both 1.5 and 3T

Laura C. Bell1 and C. Chad Quarles1

1Barrow Neurological Institute, Phoenix, AZ, United States

Several recent initiatives have focused on optimizing and standardizing DSC-MRI imaging protocols and post-processing steps. With the availability of public imaging databases that include clinical outcomes, various post-processing steps can be carefully assessed for their impact on the clinical outcomes. Here we evaluated post-processing steps for advanced perfusion biomarkers that relay on determining the residue function by examining the clinical impact of each step. In summary we determined that updating the current deconvolution steps is beneficial, and that normalization allows for tumor grading across clinical field strengths.

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