Abstract #2350

Bolus arrival time estimation for DCE-MRI signals without fast up-slope

Alina Leandra Bendinger^1,2, Charlotte Debus^3,4,5, Christin Glowa^4,5,6, Christian Peter Karger^4,6, Jörg Peter¹, and Martin Storath⁷

¹Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany, ³Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ⁵Department of Radiation Oncology and Radiotherapy, University Hospital Heidelberg, Heidelberg, Germany, ⁶Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁷Natural Sciences and Humanities, University of Applied Sciences Würzburg-Schweinfurt, Schweinfurt, Germany

Accuracy in pharmacokinetic modelling of DCE-MRI data can be impaired due to a delay between the contrast agent arrival in the tissue of interest and an artery further upstream. To correct the delay, bolus arrival times (BATs) are estimated from the concentration curves. However, the state-of-the-art method for estimating BATs may give unsatisfactory results if the curves do not exhibit a fast up-slope. We propose a spline-based method for BAT estimation for concentration curves without fast up-slopes which are often observed in small animal data. The proposed method gives accurate results on simulated and in vivo acquired rat data.

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