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Abstract #2350

Bolus arrival time estimation for DCE-MRI signals without fast up-slope

Alina Leandra Bendinger1,2, Charlotte Debus3,4,5, Christin Glowa4,5,6, Christian Peter Karger4,6, Jörg Peter1, and Martin Storath7

1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany, 3Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Heidelberg Institute for Radiation Oncology (HIRO) and National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, 5Department of Radiation Oncology and Radiotherapy, University Hospital Heidelberg, Heidelberg, Germany, 6Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 7Natural Sciences and Humanities, University of Applied Sciences Würzburg-Schweinfurt, Schweinfurt, Germany

Accuracy in pharmacokinetic modelling of DCE-MRI data can be impaired due to a delay between the contrast agent arrival in the tissue of interest and an artery further upstream. To correct the delay, bolus arrival times (BATs) are estimated from the concentration curves. However, the state-of-the-art method for estimating BATs may give unsatisfactory results if the curves do not exhibit a fast up-slope. We propose a spline-based method for BAT estimation for concentration curves without fast up-slopes which are often observed in small animal data. The proposed method gives accurate results on simulated and in vivo acquired rat data.

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