The purpose of this study is to evaluate the contribution of DWI and DSC-PWI in the peri-enhancing region for discriminating glioblastomas IDH genotypes. Further, the diagnostic value of this two MR techniques were compared with those in the enhancing portion. Features of conventional MRI, rADCmin-t, rADCmin-p, rCBVmax-t and rCBVmax-p were compared between IDH-m and IDH-w glioblastomas. IDH-mutated glioblastomas tended to present in frontal lobes and younger patients. Both rCBVmax-t and rCBVmax-p show significant difference between two subgroups, while rADCmin-t and rADCmin-p do not. The results showed that the accuracy of rCBVmax-p is higher than that of rCBVmax-t in the diagnosis of IDH-m glioblastomas. rCBVmax-p may have a better diagnostic value than rCBVmax-t in predicting IDH glioblastomas genotypes.
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