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Abstract #2355

Accuracy and precision of DCE-MRI acquired with golden-angle radial k-space under-sampling

Andrew J Fagan1, Silvin P Knight2, Matthew Clemence3, and James F Meaney2

1Radiology, Mayo Clinic, Rochester, MN, United States, 2National Centre for Advanced Medical Imaging (CAMI), St James Hospital / Trinity College University of Dublin, Dublin, Ireland, 3Philips Healthcare, Surrey, United Kingdom

The effects of using a continuous golden-angle radial k-space sampling trajectory, with varying degrees of under-sampling and compressed sensing image reconstruction, on the accuracy and precision of pharmacokinetic modeling of DCE data, were quantitatively investigated. DCE image temporal resolutions (Tres) ranging from 1.85s to 0.09s (corresponding to radial sampling densities of 100% to 4.68%) produced absolute accuracy/precision errors in all Ktrans, ve and kep values of ≤ 2%/4% (for Tres =1.85s) to ≤ 12%/11% (for Tres =0.09s), respectively. These results demonstrate that DCE image acquisition protocols can be designed which constrain pharmacokinetic parameter value errors within prescribed thresholds.

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