The effects of using a continuous golden-angle radial k-space sampling trajectory, with varying degrees of under-sampling and compressed sensing image reconstruction, on the accuracy and precision of pharmacokinetic modeling of DCE data, were quantitatively investigated. DCE image temporal resolutions (Tres) ranging from 1.85s to 0.09s (corresponding to radial sampling densities of 100% to 4.68%) produced absolute accuracy/precision errors in all Ktrans, ve and kep values of ≤ 2%/4% (for Tres =1.85s) to ≤ 12%/11% (for Tres =0.09s), respectively. These results demonstrate that DCE image acquisition protocols can be designed which constrain pharmacokinetic parameter value errors within prescribed thresholds.
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