Abstract #2356

Optimized tumor volumes by dynamic contrast enhanced MR imaging for assessing response to neoadjuvant chemotherapy in triple negative breast cancer

Benjamin Charles Musall¹, Beatriz E Adrada², Abeer H Abdelhafez², Hagar S Mahmoud², Ken-Pin Hwang¹, Jong Bum Son¹, Lumarie Santiago², Gary J Whitman², Huong Le-Petross², Tanya W Moseley², Rosalind P Candelaria², Bora Lim³, Senthil Damodaran³, Jennifer K Litton³, Stacy L Moulder³, Wei T Yang², Jingfei Ma¹, Mark D Pagel⁴, and Gaiane M Rauch²

¹Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ²Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX, United States, ³Breast Medical Oncology, MD Anderson Cancer Center, Houston, TX, United States, ⁴Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States

We evaluated several methods of measuring tumor volumes on DCE MRI for assessment of treatment response in triple negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NAC), including functional tumor volume (FTV), enhanced tumor volume(ETV), and clinical tumor volume (CTV). We compared different parameters for measurement of functional tumor volume at baseline as well as its changes during therapy, and established optimal parameters for FTV measurements. We found that optimized FTV and ETV have potential to serve as an imaging biomarker for evaluation of NAC treatment response in TNBC patients

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.