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Abstract #2360

Combined diffusion and perfusion MRI in Glioblastoma predicts glial stem cells proliferation and aggressiveness

Tanguy Duval1, Jean-Albert Lotterie1,2, Anthony LemariƩ3, Caroline Delmas3, Christine Toulas3, Elizabeth Moyal3, and Vincent Lubrano1,2

1UMR 1214 Toulouse Neuroimaging Center, INSERM, Toulouse, France, 2Department of Neurosurgery, University Hospital of Toulouse, Toulouse, France, 3U1037 Toulouse Cancer Research Center, INSERM, TOULOUSE, France

Interpretation of diffusion and perfusion MRI in the hyper-FLAIR is challenging. In this work, biopsies were extracted from 16 subjects and infiltrative tumorous stem cells were counted and cultivated intraoperatively to measure their aggressiveness. Diffusion was found to be a good predictor of the time to form tumorous neurospheres. Glioblastoma stem cells were found preferably in regions with strong perfusion, that is to say near vascular niches.

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