Abstract #2360

Combined diffusion and perfusion MRI in Glioblastoma predicts glial stem cells proliferation and aggressiveness

Tanguy Duval¹, Jean-Albert Lotterie^1,2, Anthony Lemarié³, Caroline Delmas³, Christine Toulas³, Elizabeth Moyal³, and Vincent Lubrano^1,2

¹UMR 1214 Toulouse Neuroimaging Center, INSERM, Toulouse, France, ²Department of Neurosurgery, University Hospital of Toulouse, Toulouse, France, ³U1037 Toulouse Cancer Research Center, INSERM, TOULOUSE, France

Interpretation of diffusion and perfusion MRI in the hyper-FLAIR is challenging. In this work, biopsies were extracted from 16 subjects and infiltrative tumorous stem cells were counted and cultivated intraoperatively to measure their aggressiveness. Diffusion was found to be a good predictor of the time to form tumorous neurospheres. Glioblastoma stem cells were found preferably in regions with strong perfusion, that is to say near vascular niches.

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