DWI of mice with endogenous PDAC tumours were acquired in a 7T MRI system without breath gating.
Inclusion of DWI with b-values above 800 s/mm2 in fits substantially improves the qualitative appearance and reduces variance of uniform region fit ADC.
Tumours were grouped (based on histology) by cellularity (amounts of neoplastic cells and stroma, and clustering) and separately by grade. ADC reliably distinguishes tumours of different cellularity (PDAClow 1.58±0.08; PDACmed 1.35±0.07; PDAChigh 1.17 ± 0.11; P<0.0001). Grades G2 and G3 were not distinguishable via ADC (1.43±0.15 vs. 1.43±0.16 10-3 mm2/s), however G4 had significantly lower ADC (1.16±0.10 10-3 mm2/s, P<0.0001).