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Abstract #2367

Diffusion Weighted Imaging at 7T for Differentiation by Grade and Cellularity of Murine Endogenous Pancreatic Ductal Adenocarcinoma

Irina Heid1, Geoffrey Topping2, Florian Englert1, Katja Steiger3, Ernst Rummeny1, Markus Schwaiger2, Franz Schilling2, and Rickmer Braren1

1Radiology, Technical University of Munich, Munich, Germany, 2Nuclear Medicine, Technical University of Munich, Munich, Germany, 3Institute of Pathology, Technical University of Munich, Munich, Germany

DWI of mice with endogenous PDAC tumours were acquired in a 7T MRI system without breath gating.

Inclusion of DWI with b-values above 800 s/mm2 in fits substantially improves the qualitative appearance and reduces variance of uniform region fit ADC.

Tumours were grouped (based on histology) by cellularity (amounts of neoplastic cells and stroma, and clustering) and separately by grade. ADC reliably distinguishes tumours of different cellularity (PDAClow 1.58±0.08; PDACmed 1.35±0.07; PDAChigh 1.17 ± 0.11; P<0.0001). Grades G2 and G3 were not distinguishable via ADC (1.43±0.15 vs. 1.43±0.16 10-3 mm2/s), however G4 had significantly lower ADC (1.16±0.10 10-3 mm2/s, P<0.0001).

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