Abstract #2367

Diffusion Weighted Imaging at 7T for Differentiation by Grade and Cellularity of Murine Endogenous Pancreatic Ductal Adenocarcinoma

Irina Heid¹, Geoffrey Topping², Florian Englert¹, Katja Steiger³, Ernst Rummeny¹, Markus Schwaiger², Franz Schilling², and Rickmer Braren¹

¹Radiology, Technical University of Munich, Munich, Germany, ²Nuclear Medicine, Technical University of Munich, Munich, Germany, ³Institute of Pathology, Technical University of Munich, Munich, Germany

DWI of mice with endogenous PDAC tumours were acquired in a 7T MRI system without breath gating.

Inclusion of DWI with b-values above 800 s/mm² in fits substantially improves the qualitative appearance and reduces variance of uniform region fit ADC.

Tumours were grouped (based on histology) by cellularity (amounts of neoplastic cells and stroma, and clustering) and separately by grade. ADC reliably distinguishes tumours of different cellularity (PDAC^low 1.58±0.08; PDAC^med 1.35±0.07; PDAC^high 1.17 ± 0.11; P<0.0001). Grades G2 and G3 were not distinguishable via ADC (1.43±0.15 vs. 1.43±0.16 10^-3 mm²/s), however G4 had significantly lower ADC (1.16±0.10 10^-3 mm²/s, P<0.0001).

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