Cell-encapsulating collagen-based models can be used to investigate the relative contributions of the intra and extracellular compartments to ADC, T1 and T2. ADC is mostly affected by cell density, while T2 is influenced primarily by the collagen density; a 120% reduction in T2 was seen when collagen density was increased seven-fold, but this reduction was only 80% in cell containing collagen gels. ADC was not altered by increasing collagen density, unless cell density was also increased.
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