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Abstract #2365

Longitudinal diffusion kurtosis MRI in an intracranial rat glioblastoma model

Clementine Lesbats1, Claire Kelly1, Gabriela Czanner2, and Harish Poptani1

1Centre for Preclinical Imaging, University of Liverpool, Liverpool, United Kingdom, 2Department of Applied Mathematics, Liverpool John Moores University, Liverpool, United Kingdom

Diffusion kurtosis MRI was used to evaluate the longitudinal changes in a tumor microstructure of a rat model of glioblastoma. F98 tumor cells were injected into six rat brains and imaged longitudinally 8, 11 and 14 days post-implantation. For DKI, an EPI-DTI sequence was used with 2 b-values (1000-2000 s/mm2) and 15 directions. Diffusional kurtosis parameters increased in the tumor compared to the contralateral healthy brain. No significant change with time in the tumor was observed for any diffusion or kurtosis parameters.

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