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Abstract #2373

Intravoxel Incoherent Motion Diffusion-weighted Imaging for Monitoring the Immune Response to Cyclophosphamide in C57BL/6 Mice with GL261 gliomas

Junjiao Hu1, Long Qian2, and Xiangran Cai1

1Medical image center, The First Affiliated Hospital of Jinan University, Guangzhou, China, 2MR Research China, GE Healthcare, Beijing, China

It is known that the intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) has been widely applied to the detection and characterization of tumors. However, there were no studies to investigate the use of IVIM-DWI in the evaluation of anti-neoplastic agents induced immune response. In this work, to assess whether IVIM-DWI can predict the immune response to anti-neoplastic agents, six C57BL/6 mice with GL261 mouse gliomas were applied using Metronomic cyclophosphamide. Our results indicated that IVIM-DWI is sensitive to detect the Cyclophosphamide-induced Immune Response.

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