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Abstract #2374

Correlation of breast tumor grade and lymphovascular invasion with biomechanical properties: first results from a breast cancer trial

Sweta Sethi1,2, Daniel Fovargue3, Stefan Heinz Hoelzl3, Ayse Sila Dokumaci3, Emma Burnhope3, Jurgen Runge3, Sanjay Mistry1, Keshthra Satchithananda4, Arnie Purushotham2, and Ralph Sinkus3

1Guy's and St.Thomas' NHS Foundation Trust, London, United Kingdom, 2Division of Cancer Studies, King's College London, London, United Kingdom, 3Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 4King's College Hospital, London, United Kingdom

Magnetic Resonance Elastography (MRE) has been considered a promising novel imaging modality in the quantification of viscoelastic properties of breast tumours. The purpose of this study was to evaluate reproducibility and repeatability of a newly developed MRE breast system and investigate whether aberrant biomechanical properties correlate with tumour histopathology. MRE was conducted on 20 healthy volunteers and 15 breast cancer patients. Malignant lesions demonstrated an increase in viscoelasticity when compared to adipose or fibroglandular tissue. While lesions with lymphovascular invasion demonstrated a tendency towards more elevated viscoelasticity than those without lymphovascular invasion, histological grades clearly did not correlate with biomechanics.

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