Abstract #2376

Quality assurance of quantitative MRI for biomarker discovery in locally advanced cervical cancer

Petra J van Houdt¹, Kari Tanderup², Jesper F Kallehauge², Remi A Nout³, Robert Hudej⁴, Supriya Chopra⁵, Jamema Swamidas⁵, Zdenko J van Kesteren⁶, Cornelis A.T. van den Berg⁷, Michaela Daniel⁸, Dietmar Georg⁸, Eirik Malinen⁹, Jean-Charles Côté¹⁰, Ives R Levesque¹¹, and Uulke A van der Heide¹

¹Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, Netherlands, ²Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark, ³Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands, ⁴Institute of Oncology Ljubljana, Ljubljana, Slovenia, ⁵Radiation Oncology, Tata Memorial Centre, Mumbai, India, ⁶Radiation Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands, ⁷Radiatiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, ⁸Radiotherapy, Medical University of Vienna, Vienna, Austria, ⁹Medical Physics, Oslo University Hospital, Oslo, Norway, ¹⁰Centre Hospitalier de l'Universite de Montreal, Montreal, QC, Canada, ¹¹Medical Physics Unit, McGill University, Montreal, QC, Canada

Large multi-center studies are needed to realize the utilization of quantitative MRI (qMRI) as a biomarker for cervical cancer. In this study we created a framework for a multi-center imaging biomarker study, maximizing the consistency between quantitative results in the presence of a large variety of MRI systems. This way, large deviations in qMRI values can be detected and corrected before enrolment of patients in a study. Furthermore, these results can be used to determine the statistical power of the study.

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