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Abstract #2376

Quality assurance of quantitative MRI for biomarker discovery in locally advanced cervical cancer

Petra J van Houdt1, Kari Tanderup2, Jesper F Kallehauge2, Remi A Nout3, Robert Hudej4, Supriya Chopra5, Jamema Swamidas5, Zdenko J van Kesteren6, Cornelis A.T. van den Berg7, Michaela Daniel8, Dietmar Georg8, Eirik Malinen9, Jean-Charles Côté10, Ives R Levesque11, and Uulke A van der Heide1

1Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, Netherlands, 2Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark, 3Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands, 4Institute of Oncology Ljubljana, Ljubljana, Slovenia, 5Radiation Oncology, Tata Memorial Centre, Mumbai, India, 6Radiation Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands, 7Radiatiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, 8Radiotherapy, Medical University of Vienna, Vienna, Austria, 9Medical Physics, Oslo University Hospital, Oslo, Norway, 10Centre Hospitalier de l'Universite de Montreal, Montreal, QC, Canada, 11Medical Physics Unit, McGill University, Montreal, QC, Canada

Large multi-center studies are needed to realize the utilization of quantitative MRI (qMRI) as a biomarker for cervical cancer. In this study we created a framework for a multi-center imaging biomarker study, maximizing the consistency between quantitative results in the presence of a large variety of MRI systems. This way, large deviations in qMRI values can be detected and corrected before enrolment of patients in a study. Furthermore, these results can be used to determine the statistical power of the study.

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