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Abstract #2377

The value of 1.5T contrast-enhanced T1 SPACE sequence in the simulation and planning for Cyberknife stereotactic radiosurgery of brain metastases: patient positioning accuracy, lesion detectability, and target delineation reliability

Jing Yuan1, Oilei Wong1, Winky WK Fung2, Gladys G Lo3, Franky KF Cheng2, Yihang Zhou1, George Chiu2, Kin Yin Cheung1, and Siu Ki Yu1

1Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, 2Department of radiotherapy, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, 3Department of Diagnostic and Interventional Radiology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong

Stereotactic radiosurgery (SRS) is increasingly used for multiple brain metastases (BM) treatment and imposes critical requirements on the accuracy of BM detection, localization and definition in the treatment planning. SPACE sequence is valuable in BM detection for diagnosis, while its value in the BM SRS planning has rarely been explored. We prospectively and quantitatively assessed CE-T1-SPACE in the treatment simulation and planning of Cyberknife-guided BM SRS on a 1.5T MRI-simulator. The results showed that CE-T1-SPACE facilitated high patient positioning accuracy, superior BM detectability and reliable GTV delineation, showing great value in the treatment planning of BM SRS.

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