Stereotactic radiosurgery (SRS) is increasingly used for multiple brain metastases (BM) treatment and imposes critical requirements on the accuracy of BM detection, localization and definition in the treatment planning. SPACE sequence is valuable in BM detection for diagnosis, while its value in the BM SRS planning has rarely been explored. We prospectively and quantitatively assessed CE-T1-SPACE in the treatment simulation and planning of Cyberknife-guided BM SRS on a 1.5T MRI-simulator. The results showed that CE-T1-SPACE facilitated high patient positioning accuracy, superior BM detectability and reliable GTV delineation, showing great value in the treatment planning of BM SRS.
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