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Abstract #2389

Characterization of the arrest and retention of iron-labeled breast cancer cells and the growth and progression of brain metastases in NSG mice

Natasha Knier1,2, Amanda M. Hamilton1, Ashley V. Makela1,2, and Paula J. Foster1,2

1Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, The University of Western Ontario, London, ON, Canada

Patient-derived xenografts in NSG mice provide a novel and more clinically relevant model of studying breast cancer brain metastasis in comparison to traditional cell lines in nude mice. NSG and nude mice both received brain-seeking breast cancer cells and were imaged with MRI to assess cell arrest, retention, and growth. Images revealed significantly more brain metastases and overall whole-body tumour burden in NSG mice than nudes. These results provide characterization of the NSG mouse as a preclinical platform for PDX models and demonstrates the importance of imaging to establish this model for future advancements in drug development and personalized medicine.

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