Abstract #2389

Characterization of the arrest and retention of iron-labeled breast cancer cells and the growth and progression of brain metastases in NSG mice

Natasha Knier^1,2, Amanda M. Hamilton¹, Ashley V. Makela^1,2, and Paula J. Foster^1,2

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, The University of Western Ontario, London, ON, Canada

Patient-derived xenografts in NSG mice provide a novel and more clinically relevant model of studying breast cancer brain metastasis in comparison to traditional cell lines in nude mice. NSG and nude mice both received brain-seeking breast cancer cells and were imaged with MRI to assess cell arrest, retention, and growth. Images revealed significantly more brain metastases and overall whole-body tumour burden in NSG mice than nudes. These results provide characterization of the NSG mouse as a preclinical platform for PDX models and demonstrates the importance of imaging to establish this model for future advancements in drug development and personalized medicine.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.