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Abstract #2398

A novel imaging biomarker for cancer from multicomponent T1 relaxometry

Ana-Maria Oros1, Anna Weglage2, and N. Jon Shah2,3,4,5

1Institute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine (INM-4), Research Centre Juelich, Juelich, Germany, 3JARA-BRAIN-Translational Medicine, Research Centre Juelich, Aachen, Germany, 4Institute of Neuroscience and Medicine (INM-11, JARA), Research Centre Juelich, Juelich, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

We hypothesised that T1 relaxation curves sampled with very high temporal resolution reflect the existence of several environments in healthy and brain tumour tissue. Relaxation properties of healthy as well as tumour tissue, identified by FET-PET in a hybrid MR-PET environment, were investigated using a Look-Locker inversion recovery sequence sampled with a 17ms time resolution and 460 time points. The properties of normal appearing tissue were very similar in patients and healthy volunteers. In addition, a novel component was identified in brain tumour patients, which seems characteristic of the presence of tumour and oedema.

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