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Abstract #2397

3D non-rigid motion correction for quantitative assessment of hepatic lesions with dynamic contrast enhanced MRI

Matteo Ippoliti1, Tobias Schaeffter2, Marcus Richard Makowski1, and Christoph Kolbitsch2

1Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany

Dynamic Contrast Enhanced (DCE) MRI of the liver is a powerful qualitative and quantitative clinical methodology used to identify lesions and characterize their functional behavior. Respiratory motion can lead to artefacts, impairing the calculation of contrast uptake curves and quantitative functional information. Here we present an approach, which provides non-rigid motion-corrected endothelial permeability (Ktrans) maps obtained from DCE images with temporal resolution of 6s and isotropic spatial resolution of 1.5mm3 acquired during free-breathing. The proposed framework was evaluated in 10 patients and led to an improved visualization of hepatic lesions and subsequent derivation of Ktrans maps.

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