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Abstract #2466

Signal intensity form of Tofts model for quantitative analysis of dynamic contrast enhanced MRI data

Xiaobing Fan1, Aritrick Chatterjee1, Aytekin Oto1, and Gregory S. Karczmar1

1Radiology, University of Chicago, Chicago, IL, United States

The Tofts pharmacokinetic model requires contrast agent concentration as function of time (C(t)), which is normally calculated using the non-linear model that could contribute some errors. Here, we present signal intensity (S(t)) form of standard Tofts pharmacokinetic model without calculating C(t). Human prostate DCE-MRI data were analyzed to compare physiological parameters calculated from the Tofts model using S(t) and C(t). The Ktrans and ve calculated from S(t) were correlated strongly with the values calculated from C(t). Bland–Altman analysis showed moderate to good agreement between for the Ktrans and ve calculated from Tofts model with S(t) and C(t).

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