Abstract #2466

Signal intensity form of Tofts model for quantitative analysis of dynamic contrast enhanced MRI data

Xiaobing Fan¹, Aritrick Chatterjee¹, Aytekin Oto¹, and Gregory S. Karczmar¹

¹Radiology, University of Chicago, Chicago, IL, United States

The Tofts pharmacokinetic model requires contrast agent concentration as function of time (C(t)), which is normally calculated using the non-linear model that could contribute some errors. Here, we present signal intensity (S(t)) form of standard Tofts pharmacokinetic model without calculating C(t). Human prostate DCE-MRI data were analyzed to compare physiological parameters calculated from the Tofts model using S(t) and C(t). The K^trans and v_e calculated from S(t) were correlated strongly with the values calculated from C(t). Bland–Altman analysis showed moderate to good agreement between for the K^trans and v_e calculated from Tofts model with S(t) and C(t).

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