The Tofts pharmacokinetic model
requires contrast agent concentration as function of time (C(t)), which is normally
calculated using the non-linear model that could contribute some errors. Here,
we present signal intensity (S(t)) form of standard Tofts pharmacokinetic model
without calculating C(t). Human prostate DCE-MRI data were analyzed to compare
physiological parameters calculated from the Tofts model using S(t) and C(t).
The Ktrans and ve calculated from S(t) were correlated
strongly with the values calculated from C(t). Bland–Altman
analysis showed moderate to good agreement between for the Ktrans
and ve calculated from Tofts model with S(t) and C(t).