Meeting Banner
Abstract #2499

Spectral Editing of NAD+/NADH in 31P NMR spectra of Human Brain

Jimin Ren1,2, A Dean Sherry1,2,3, and Craig R Malloy1,2,4

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States, 4VA North Texas Health Care System, Dallas, TX, United States

Nicotinamide adenine dinucleotides (NAD+/NADH) play an essential role in cellular redox reactions and many biological processes. Altered NAD+/NADH levels and redox state may be associated with development of neurodegenerative diseases and psychotic disorders. 31P MRS is currently the only non-invasive technique to measure NAD+/NADH levels and redox state in human brain in vivo. However, the present technique suffers two major drawbacks: (1) the severe overlapping of the NAD+/NADH signals with the α-ATP resonance, and (2) the distorted baseline underneath these signals. Here we present a novel spectral editing method that allows resolution of NAD+/NADH from α-ATP at baseline.

This abstract and the presentation materials are available to members only; a login is required.

Join Here