Abstract #2499

Spectral Editing of NAD+/NADH in 31P NMR spectra of Human Brain

Jimin Ren^1,2, A Dean Sherry^1,2,3, and Craig R Malloy^1,2,4

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States, ⁴VA North Texas Health Care System, Dallas, TX, United States

Nicotinamide adenine dinucleotides (NAD+/NADH) play an essential role in cellular redox reactions and many biological processes. Altered NAD+/NADH levels and redox state may be associated with development of neurodegenerative diseases and psychotic disorders. ³¹P MRS is currently the only non-invasive technique to measure NAD+/NADH levels and redox state in human brain in vivo. However, the present technique suffers two major drawbacks: (1) the severe overlapping of the NAD+/NADH signals with the α-ATP resonance, and (2) the distorted baseline underneath these signals. Here we present a novel spectral editing method that allows resolution of NAD+/NADH from α-ATP at baseline.

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