Abstract #2500

Fast Quantification of Creatine Kinase Reaction Rate in Mouse Skeletal Muscle Using 31P Magnetic Resonance Fingerprinting

Kihwan Kim¹, Charlie Wang ², Yuning Gu², Shuying Huang², Bryan Clifford³, Zhi-Pei Liang⁴, and Xin Yu²

¹Biomedical Engineering, Case Western Reserve University, cleveland, OH, United States, ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, OH, United States

We evaluated the accuracy and efficiency of a ³¹P magnetic resonance fingerprinting (MRF) method for fast measurement of the creatine kinase (CK) rate constant in mouse skeletal muscle. Our results showed consistent measurement of CK rate constant with less than 10% variations with only 6 signal averages, corresponding to 2 min acquisition.

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