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Abstract #2502

Dynamic 31P-MRSI of Human Calf Muscles using Compressed Sensing and a Low Rank Reconstruction

Alejandro Santos Diaz1,2, Diana Harasym1,2, and Michael Noseworthy1,2,3

1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 2Imaging Research Center, St. Joseph's Healthcare, Hamilton, ON, Canada, 3Electrical and Computing Engineering, McMaster University, Hamilton, ON, Canada

Dynamic 31P-MRSI experiments require temporal resolution on the order of seconds to concurrently assess metabolic change in different muscles. In this study we developed a pulse sequence using a flyback-EPSI readout combined with compressed sensing (CS) to achieve a 9 second temporal resolution and tested it in 11 healthy volunteers during an exercise-recovery challenge of the lower leg muscles. Our results showed that the sequence was capable of assessing PCr depletion/recovery and intracellular pH at rest and following exercise, of multiple muscle groups simultaneously, using a clinical 3T MR system.

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