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Abstract #2503

Dependence of 31P MRS Redox Ratio on T1 Saturation

Shizhe Steve Li1, Jan Willem van der Veen1, Li An1, JoEllyn Stolinski1, Maria Ferraris-Araneta1, Christopher Johnson1, and Jun Shen1

1National Institutes of Health, Bethesda, MD, United States

31P measurement of the oxidized (NAD+) and reduce form (NADH) of nicotinamide adenine dinucleotide has been applied to in vivo assessment of the redox state of the brain. Since uridine diphosphate glucose (UDPG) overlaps with the nicotinamide adenine dinucleotide peaks we examined the effect of changes in the relative intensities of the UDPG basis components on quantification of the redox ratio. We found that the fitted redox ratio is significantly dependent on the UDPG basis whose chemically distinct components are subject to different T1 saturation effect in vivo.

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