Abstract #2506

Nutritional ketosis increases NAD+/NADH ratio in healthy human brain: an in vivo study by 31P-MRS

Lijing Xin¹, Özlem Ipek¹, Maurice Beaumont², Maya Shevlyakova², Nicolas Christinat³, Mojgan Masoodi³, Norman Greenberg⁴, Rolf Gruetter^1,5, and Bernard Cuenoud⁴

¹Center for Biomedical Imaging, École polytechnique fédérale de Lausanne, Lausanne, Switzerland, ²Clinical Development Unit, Nestlé Research Center, Lausanne, Switzerland, ³Nestlé Institute of Health Sciences SA, Lausanne, Switzerland, ⁴Nestlé Health Science, Epalinges, Switzerland, ⁵Department of radiology, University of Lausanne and Geneva, Lausanne and Geneva, Switzerland

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.

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