Meeting Banner
Abstract #2506

Nutritional ketosis increases NAD+/NADH ratio in healthy human brain: an in vivo study by 31P-MRS

Lijing Xin1, Özlem Ipek1, Maurice Beaumont2, Maya Shevlyakova2, Nicolas Christinat3, Mojgan Masoodi3, Norman Greenberg4, Rolf Gruetter1,5, and Bernard Cuenoud4

1Center for Biomedical Imaging, École polytechnique fédérale de Lausanne, Lausanne, Switzerland, 2Clinical Development Unit, Nestlé Research Center, Lausanne, Switzerland, 3Nestlé Institute of Health Sciences SA, Lausanne, Switzerland, 4Nestlé Health Science, Epalinges, Switzerland, 5Department of radiology, University of Lausanne and Geneva, Lausanne and Geneva, Switzerland

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD+/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.

This abstract and the presentation materials are available to members only; a login is required.

Join Here