Meeting Banner
Abstract #2507

Metabolic fate of glucose in atypical meningioma studied by 13C NMR isotopomer analysis

Kumar Pichumani1, Omkar B Ijare1, and David S Baskin1

1Neurosurgery, Houston Methodist Hospital and Research Institute, Houston, TX, United States

Meningiomas are tumors arising from meninges, the membranes surrounding the brain and the spinal cord. Majority of meningiomas (grade-1) are benign and grow slowly. However, atypical meningiomas (grade-2) exhibit increased cellular abnormalities, and grow at a faster rate than benign meningiomas. Moreover, atypical meningiomas prone to recurrence and show resistance to radiotherapy. Atypical meningiomas show higher 18F-FDG uptake in PET scans. No prior reports are available on investigating metabolic fate of glucose in atypical meningiomas. The goal of this study is to probe the metabolic fate of glucose using NMR based [U-13C]glucose isotopic tracing methods in patient-derived atypical meningioma cells.

This abstract and the presentation materials are available to members only; a login is required.

Join Here