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Abstract #2512

Combined 23Na/39K MRI for the quantification of Na+ and K+ concentrations in human skeletal muscle at 7 T

Lena V. Gast1, Max Müller1, Bernhard Hensel2, Michael Uder1, and Armin M. Nagel1,3

1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Center for Medical Physics and Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

A non-invasive determination of Na+ and K+ concentrations in skeletal muscle tissue is desirable to gain insights into pathological processes connected to various diseases. In this work, the feasibility of combined quantitative 23Na/39K MRI at 7 T using a double-tuned 23Na/39K birdcage calf coil was examined. In phantom measurements, a 23Na/39K SNR ratio of 46.8 was found. Moreover, Na+ and K+ concentrations close to the real concentrations were determined. In skeletal muscle tissue, fast transverse relaxation of 39K leads to underestimation of K+ concentrations if no relaxation correction is applied.

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