Abstract #2512

Combined 23Na/39K MRI for the quantification of Na+ and K+ concentrations in human skeletal muscle at 7 T

Lena V. Gast¹, Max Müller¹, Bernhard Hensel², Michael Uder¹, and Armin M. Nagel^1,3

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Center for Medical Physics and Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

A non-invasive determination of Na⁺ and K⁺ concentrations in skeletal muscle tissue is desirable to gain insights into pathological processes connected to various diseases. In this work, the feasibility of combined quantitative ²³Na/³⁹K MRI at 7 T using a double-tuned ²³Na/³⁹K birdcage calf coil was examined. In phantom measurements, a ²³Na/³⁹K SNR ratio of 46.8 was found. Moreover, Na⁺ and K⁺ concentrations close to the real concentrations were determined. In skeletal muscle tissue, fast transverse relaxation of ³⁹K leads to underestimation of K⁺concentrations if no relaxation correction is applied.

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