Abstract #2517

Measurement of Intraneurite Sodium Concentration from NODDI-based Partial Volume Correction of in vivo 23Na MRI

Iris Asllani^1,2, Guillaume Madelin³, Marco Bozzali^1,4, and Mara Cercignani^1,4

¹Neuroscience, Brighton and Sussex Medical School, Brighton, United Kingdom, ²Biomedical Engineering, Rochester Institute of Technology, Rochester, NY, United States, ³Radiology, New York University School of Medicine, New York, NY, United States, ⁴Neuroimaging, Santa Lucia Foundation, Rome, Italy

The sodium ion plays a crucial role in maintaining healthy brain function and metabolism. Changes in sodium concentration measured with ²³Na MRI have been implicated in several diseases in the brain and other organs. However, due to SNR and scanning time requirements, ²³Na MRI remains a low resolution technique hampered by partial volume effects. Here, we combined a partial volume correction (PVC) algorithm, previously used in Arterial Spin Labeling perfusion MRI, with Neurite Orientation Dispersion and Density Imaging (NODDI) to extract sodium concentration values from intra- and extra-neurite compartments in the brain in vivo using ²³Na MRI at 3T.

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