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Abstract #2517

Measurement of Intraneurite Sodium Concentration from NODDI-based Partial Volume Correction of in vivo 23Na MRI

Iris Asllani1,2, Guillaume Madelin3, Marco Bozzali1,4, and Mara Cercignani1,4

1Neuroscience, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Biomedical Engineering, Rochester Institute of Technology, Rochester, NY, United States, 3Radiology, New York University School of Medicine, New York, NY, United States, 4Neuroimaging, Santa Lucia Foundation, Rome, Italy

The sodium ion plays a crucial role in maintaining healthy brain function and metabolism. Changes in sodium concentration measured with 23Na MRI have been implicated in several diseases in the brain and other organs. However, due to SNR and scanning time requirements, 23Na MRI remains a low resolution technique hampered by partial volume effects. Here, we combined a partial volume correction (PVC) algorithm, previously used in Arterial Spin Labeling perfusion MRI, with Neurite Orientation Dispersion and Density Imaging (NODDI) to extract sodium concentration values from intra- and extra-neurite compartments in the brain in vivo using 23Na MRI at 3T.

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