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Abstract #2516

Comparison of Relaxometry-Weighted Sodium MRI and IDH Status in Cerebral Gliomas

Aliaksandra Shymanskaya1, Wieland A. Worthoff2, Karl-Josef Langen2,3,4, and N. Jon Shah1,2,3,5

1Forschungszentrum Juelich, INM-11, Juelich, Germany, 2Forschungszentrum Juelich, INM-4, Juelich, Germany, 3JARA - BRAIN - Translational Medicine, Aachen, Germany, 4Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

Patients with cerebral gliomas were investigated using an enhanced SISTINA sequence to estimate sodium relaxation and its correlation to the IDH mutational status. Sodium MRI is used for the indirect assessment of sodium relaxation parameters through the relative change at two echo times in tumour and contralateral tissue. Sodium signals attributed to mostly restricted and non-restricted sodium are differentiated through the development of multiple quantum coherences. Changes in relaxation rates in total sodium correlate to the IDH mutational status on short time scale. This correlation could be caused by the change in sodium distribution in different compartments in diseased tissue.

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