Abstract #2519

Ouabain Inhibition Reverses Sodium Fluxes in a Preclinical Model of Migraine: a 23Na MRI Study at 21.1 T

Nastaren Abad^1,2, David Hike^1,2, Jens T Rosenberg², Michael G Harrington³, and Samuel C Grant^1,2

¹Chemical and Biomedical Engineering, Florida State University, Tallahassee, FL, United States, ²National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ³Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States

Increased sodium potassium ATPase(Na,K-ATPase) pump activity raises cerebrospinal fluid and brain sodium, resulting in the onset and progression of central sensitization [1-4]. With the goal of testing whether impaired Na,K-ATPase activity is implicit in the onset of migraine, this study makes use of ouabain to inhibit Na,K-ATPase activity and delineate sodium changes that may lie at the heart of migraine. At high spatial and temporal resolution, ²³Na multislice CSI scans were acquired from a rodent migraine model, at 21.1 T following the onset or potential inhibition of central sensitization to identify localized sodium changes over 3-h after induction.

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