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Abstract #2519

Ouabain Inhibition Reverses Sodium Fluxes in a Preclinical Model of Migraine: a 23Na MRI Study at 21.1 T

Nastaren Abad1,2, David Hike1,2, Jens T Rosenberg2, Michael G Harrington3, and Samuel C Grant1,2

1Chemical and Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 2National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 3Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States

Increased sodium potassium ATPase(Na,K-ATPase) pump activity raises cerebrospinal fluid and brain sodium, resulting in the onset and progression of central sensitization [1-4]. With the goal of testing whether impaired Na,K-ATPase activity is implicit in the onset of migraine, this study makes use of ouabain to inhibit Na,K-ATPase activity and delineate sodium changes that may lie at the heart of migraine. At high spatial and temporal resolution, 23Na multislice CSI scans were acquired from a rodent migraine model, at 21.1 T following the onset or potential inhibition of central sensitization to identify localized sodium changes over 3-h after induction.

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