Abstract #2529

1 H MRS Analysis of Pancreas Metabolites altered by Cachexia

Raj Kumar Sharma¹, Santosh K. Bharti¹, Paul T. Winnard Jr¹, Yelena Mironchik¹, Marie-France Penet^1,2, and Zaver M. Bhujwalla^1,2,3

¹Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cancer induced cachexia is a syndrome characterized by tissue wasting and weight loss. Cachexia occurs with the highest frequency and severity in pancreatic ductal adenocarcinoma (PDAC). To further understand this syndrome, we used 1H MRS to analyze pancreas metabolites in mice with and without cachexia-inducing PDAC xenografts. We detected significant weight loss in cachectic mice. 1H MR spectra identified significant differences in amino acids, BCAA, alanine, pyruvate, phosphocholine, niacinamide and NAD in cachectic mice that provide new insights into the morbidity and mortality associated with the syndrome that may lead to novel strategies to arrest this syndrome.

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