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Abstract #2530

Chemical deregulation in breast tissue of women at familial high risk of breast cancer correlates with the IBIS Breast Cancer Risk Evaluator Tool using 2D COSY at 3 Tesla

Natali Naude1, Gorane Santamaria2, Graham Galloway3, Chris Foster4, Aaron Urquhart3, Thomas Gaass5, Saadallah Ramadan6, Scott Quadrelli7, Lisa Rich8, Ian Bennett7, Jessica Buck6, Peter Malycha3, and Carolyn Mountford3

1Queensland University of Technology/Translational Research Institute, Brisbane, Australia, 2Princess Alexandra Hospital/Translational Research Institute, Brisbane, Australia, 3Translational Research Institute, Brisbane, Australia, 4Translational Research Institute, Woolloongabba, Australia, 5Siemens, Brisbane, Australia, 6University of Newcastle, Newcastle, Australia, 7Princess Alexandra Hospital, Brisbane, Australia, 8Translational Research Institute/Princess Alexandra Hospital, Brisbane, Australia

Evaluation of breast tissue of women with a high familial risk of developing breast cancer using in vivo 2D COSY as part of a standard 3T breast MRI showed statistically significant alterations in the type of double bonds in fatty acyl chains compared with controls. Further, when separating the familial cohort using the IBIS risk evaluatior tool into a group above and below 20% lifetime risk, statistically significant differences in both cholesterol and metabolites were recorded.

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