Abstract #2530

Chemical deregulation in breast tissue of women at familial high risk of breast cancer correlates with the IBIS Breast Cancer Risk Evaluator Tool using 2D COSY at 3 Tesla

Natali Naude¹, Gorane Santamaria², Graham Galloway³, Chris Foster⁴, Aaron Urquhart³, Thomas Gaass⁵, Saadallah Ramadan⁶, Scott Quadrelli⁷, Lisa Rich⁸, Ian Bennett⁷, Jessica Buck⁶, Peter Malycha³, and Carolyn Mountford³

¹Queensland University of Technology/Translational Research Institute, Brisbane, Australia, ²Princess Alexandra Hospital/Translational Research Institute, Brisbane, Australia, ³Translational Research Institute, Brisbane, Australia, ⁴Translational Research Institute, Woolloongabba, Australia, ⁵Siemens, Brisbane, Australia, ⁶University of Newcastle, Newcastle, Australia, ⁷Princess Alexandra Hospital, Brisbane, Australia, ⁸Translational Research Institute/Princess Alexandra Hospital, Brisbane, Australia

Evaluation of breast tissue of women with a high familial risk of developing breast cancer using in vivo 2D COSY as part of a standard 3T breast MRI showed statistically significant alterations in the type of double bonds in fatty acyl chains compared with controls. Further, when separating the familial cohort using the IBIS risk evaluatior tool into a group above and below 20% lifetime risk, statistically significant differences in both cholesterol and metabolites were recorded.

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