Abstract #2532

Whole-brain high resolution 3D MRSI for measuring 2HG and tumor metabolism in mutant IDH glioma patients

Bernhard Strasser¹, Borjan Gagoski^2,3, Bijaya Thapa⁴, Xianqi Li⁴, Wolfgang Bogner⁵, Julia Small⁶, Jorg Dietrich⁷, Daniel P. Cahill⁶, Tracy T. Batchelor⁷, and Ovidiu C. Andronesi⁴

¹Department of Radiology, MGH, A.A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ⁵Department of Radiology, Medical University of Vienna, Vienna, Austria, ⁶Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States, ⁷Department Neurology, Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, United States

2-Hydroxyglutarate (2HG) detection using MRSI is a very promising, but challenging technique. Although high-resolution MRSI reduces the already small SNR of 2HG, it also reduces the spectral linewidth and provides more voxels for quantification. This study compares two high-resolution spiral MRSI sequences with a low-resolution MEGA-edited sequence, and one with a short echo time for 2HG detection in brain tumor patients. Three patients and three volunteers were measured with all four sequences. The two high-resolution sequences perform better with less false-positive 2HG detection in volunteers, and a more reliable 2HG quantification in IDH-mutated tumors.

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