Isocitrate dehydrogenase (IDH) mutation is common in grade II and grade III gliomas, and results in better patient prognosis IDH mutant (IDH-mut) gliomas. Magnetic resonance spectroscopy (MRS) studies indicated an increase in 2-hydroxyglutarate (2HG) and decrease in glutamate (Glu) and glutathione (GSH) as a result of IDH mutation. The goal of this study is to compare IDH mutation classification performances of short echo-time (TE) PRESS and MEGA-PRESS by using machine learning in 60 glioma patients. Highest average classification accuracy was 75% with coarse decision trees for short TE PRESS, and 74% with ensemble of bagged of trees for MEGA-PRESS.
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