Abstract #2534

Metabolic Markers of Disease Progression in Pediatric Diffuse Intrinsic Pontine Gliomas

Stefan Bluml^1,2, Brenda Kurland³, Marvin D Nelson¹, Benita Tamrazi¹, Rafael Ceschin⁴, Ian F Pollack⁵, and Ashok Panigrahy⁴

¹Radiology, Children's Hospital Los Angeles/USC, Los Angeles, CA, United States, ²Rudi Schulte Research Institute, Santa Barbara, CA, United States, ³Biostatistics, UPMC Children's Hopital of Pittsburgh, Pittsburgh, PA, United States, ⁴Radiology, UPMC Children's Hopital of Pittsburgh, Pittsburgh, PA, United States, ⁵Neurosurgery, UPMC Children's Hopital of Pittsburgh, Pittsburgh, PA, United States

Diffuse intrinsic pontine gliomas (DIPG) are inoperable and highly resistant to chemo- and radiation therapy. DIPG carry the worst prognosis among pediatric brain tumors with progress in the development of therapies compromised by low patient numbers and unavailability of tissue samples to characterize disease status. In this work we present evidence, that non-invasive MR spectroscopy can provide robust early indicators that can assess the effectiveness (or ineffectiveness) of potential new therapeutic approach at an early stage and accelerate the completion of clinical trials in small cohorts of patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.