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Abstract #2542

The Potential Impact of Multiparametric MRS in the Early Detection of Neurodegeneration in Multiple Sclerosis

Assaf Tal1 and Ivan Kirov2

1Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Radiology, New York University, New York, NY, United States

Clinical proton MRS conventionally measures metabolites' concentrations, but neglects to acquire their relaxation constants, despite the fact that these are known to vary in many pathologies. Using computer simulations and literature values for n-acetyl-aspartate, we show that incorporating this additional information can greatly facilitate the detection of neurodegeneration in early stage multiple sclerosis (MS), increasing the area under the corresponding receiver operating characteristic curves from 0.68 to 0.91. These results strongly motivate the need for developing robust sequences for clinical multiparametric magnetic resonance spectroscopy .

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