Abstract #2543

Mapping of Regional Distributions of Brain Metabolites in Healthy Young Adults using Three-dimensional Echoplanar Spectroscopic Imaging

Eric Petersen¹, David Roalf¹, Ruben Gur¹, Raquel Gur¹, Andrew Crow¹, Ravinder Reddy², Sumei Wang², Suyash Mohan², Andrew Maudsley³, and Sanjeev Chawla²

¹Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ³Radiology, University of Miami, Miami, FL, United States

To determine the regional distributions of metabolites from different lobar regions of brain in a cohort of healthy individuals in late adolescence and early adulthood, a total of 19 subjects (mean age=22) underwent 3D-echoplanar spectroscopic imaging. The parametric maps of N-acetylaspartate (NAA), creatine (tCr), choline (tCho), myoinositol (mI) and glutamate/glutamine (Glx) were generated using sophisticated post-processing steps. These maps were normalized to MNI atlas. Significant spatial variations in metabolite ratios of NAA/tCr, tCho/tCr, mI/tCr and Glx/tCr were observed across different lobar regions of brain. These findings will undergird future efforts to understand metabolite distributions in neurodevelopmental disorders.

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