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Abstract #2544

7T 1H-MRS of the anterior cingulate in patients with psychosis spectrum and mood symptoms

Eric Petersen1, Sanjeev Chawla2, Andrew Crow1, Theodore Satterthwaite1, Raquel E Gur1, Ruben C Gur1, Ravi Prakash Reddy Nanga2, Hari Hariharan2, Mark Elliott2, Ravinder Reddy2, and David R Roalf1

1Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States

Data from 12 typically developing (TD), 10 clinical high risk for psychosis (CHR), 6 psychosis (PSY) and 4 mood disorder (MD) participants who underwent 1HMRS at 7T. Short TE single voxel spectra (SVS) were obtained using a custom-modified PRESS sequence from the anterior cingulate gyrus. Data quality was high and tissue contribution within the acquisition voxel was similar across diagnostic groups. NAA, Creatine, Choline, GSH and Glu were significantly lower in PSY as compared to TD. CHR showed an intermediate pattern for all brain neurometabolites, except GSH, which was elevated as compared to TD. MD patients, in general, showed higher concentrations of NAA, Cho, GSH and Glu as compared to TD.

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