Abstract #2576

Olfactory bulb atrophy and smell deficits in H&Y stage-1 Parkinson’s disease

Rachel S Stanford¹, Lauren Spreen¹, Thyagarajan Subramanian², Qing X Yang¹, and Jianli Wang¹

¹Radiology, Penn State University, Hershey, PA, United States, ²Neurology, Penn State University, Hershey, PA, United States

The olfactory bulb (OB) is highly affected by Lewy bodies, the hallmark pathology of Parkinson's disease (PD). Hyposmia has been reported to occur in the majority of early-stage PD patients. We investigated whether there is olfactory bulb atrophy in early-stage PD patients. Our data demonstrated significantly reduced olfactory bulb volumes as well as lower psychophysical smell test scores in H&Y stage-1 PD patients compared to healthy controls.

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