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Abstract #2577

Meta-analysis of the diagnostic effect size of neuromelanin MRI in Parkinson’s disease

Abdul Halim Sapuan1, Saadnah Naidu1, Stefan Schwarz1, Yue Xing1, and Dorothee P Auer1

1Department of Radiological Sciences, University of Nottingham, Nottingham, United Kingdom

The clinical diagnosis and monitoring of Parkinson’s disease (PD) remain challenging which prompted substantial research efforts to develop pathophysiological meaningful biomarkers. Depigmentation of the substantia nigra (SN), pars compacta, is a pathological hallmark of PD that can be detected by neuromelanin-sensitive MRI (NM-MRI). We undertook a meta-analysis on the pooled diagnostic accuracy of NM-MRI in 14 case-control studies including 755 subjects (427 PD). We show a consistent decrease of SN NM signal in PD vs controls independent of the acquisition and analysis methods with a pooled standardized mean difference of SMD=1.06, 95% CI, 0.84, 1.28, p<0.00001. In conclusion, this meta-analysis supports NM-MRI metrics as a diagnostic biomarker of PD.

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