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Abstract #2578

Utility of Quantitative Susceptibility Mapping & Diffusion Kurtosis Imaging in the Diagnosis of Early Idiopathic Parkinson’s Disease

Septian Hartono1, Samantha Tan2, Ann Chu Ning1, Soo Lee Lim3, Tong San Koh2,4, Ming-Ching Wen1, Huihua Li3, Fiona Setiawan1, Samuel Ng1, Nicole Chia1, Saifeng Liu5, Mark Haacke6, Eng King Tan1,2, Louis Tan1,2, and Ling Ling Chan2,3

1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Graduate Medical School, Singapore, Singapore, 3Singapore General Hospital, Singapore, Singapore, 4National Cancer Centre Singapore, Singapore, Singapore, 5MRI Institute for Biomedical Research, Bingham Farms, MI, United States, 6Wayne State University, Detroit, MI, United States

Parkinson's disease (PD) is characterised by dopaminergic neuronal loss and iron overload in the nigrostriatum. Diffusion Kurtosis Imaging (DKI) and Quantitative Susceptibility Mapping (QSM) allow quantification of alterations in tissue microstructure based on water diffusion and iron deposition respectively. Our case-control study in PD using DKI revealed greater cellular loss in the lateral SN and complex microstructural degradation in the putamen. QSM showed spatially variant iron deposition (Δχ) in the grey nuclei congruent with histochemical reports, and multivariate analysis showed that putaminal and lateral nigral Δχ significantly predicted UPDRS. Significant correlations between Δχ and DKI indices were found in the putamen.

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