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Abstract #2584

Voxel-Based Meta-Analysis of Mutant α-Synuclein transgenic Marmoset using Multiparametric MRI

Mai Mizumura1, Fumiko Seki2,3, Junichi Hata2, Yawara Haga1, Marin Nishio3, Hideyuki Okano2, and Akira Furukawa4

1Center for Brain Science, RIKEN, Wako, Japan, 2Keio University School of Medicine, Tokyo, Japan, 3Central Institute for Experimental Animals, Kanagawa, Japan, 4Tokyo Metropolitan University Graduate School, Tokyo, Japan

In this study, we evaluated the characteristics of the brain in a genetically modified marmoset model of Parkinson’s disease. Various contrast images were acquired using magnetic resonance imaging (MRI), and the whole brain underwent explorative investigation with each contrast. For each image, statistical evaluation was performed using SPM. Diffusion tensor MRI showed significance differences in the thalamus, while magnetization transfer ratio images showed a significant difference in the nigral striatum. The findings suggest that the marmoset is useful as a model animal to study human diseases.

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