Meeting Banner
Abstract #2593

Functional Brain Connectome and Mild Cognitive Impairment in Early Stage Parkinson Disease

Xueling Suo1, Du Lei1, Nannan Li2, Wenbin Li1, Lan Cheng2, Meiyun Wang3, Rong Peng2, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Neurology, West China Hospital of Sichuan University, Chengdu, China, 3Department of Radiology, Henan Provincial People’s Hospital & the People’s Hospital of Zhengzhou University, Zhengzhou, China

To use graph theory approaches and resting-state functional magnetic resonance imaging (MRI) to explore the brain functional network in patients with early stage Parkinson's disease (PD) and mild cognitive impairment (MCI). The whole-brain functional network was constructed by thresholding the Pearson correlation matrices of 90 brain regions. The results showed a less small-worldization characterized by decreased global integration and decreased local segregation in PD patients relative to healthy controls (HC). On the basis of these between-group difference in global and nodal properties, PD patients with MCI showed the lowest properties values, followed by PD patients with normal cognition and HC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here