Parkinson’s disease is a progressive, neurodegenerative disorder characterized by asymmetrical onset of motor symptoms such as bradykinesia, rigidity, and tremor. Mounting evidence suggests that the cerebellum plays a major role in the pathophysiology of PD. Prior imaging studies have found altered cerebellar activation during motor execution and motor learning, suggesting that altered activation in the cerebellum may reflect Parkinsonian-related impairment. Here, we use resting-state function MRI (fMRI) to ascertain connectivity changes in the cerebellum from Parkinson's disease found reduced connectivity in lobule V of the cerebellum as well as reduced connectivity between dentate nucleus and the cerebellar cortex.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords