Abstract #2595

Disruption of cortical-basal ganglia motor network affects cognitive function in Parkinson’s disease: a high angular resolution diffusion imaging study

Chenfei Ye¹, Zehong Yan¹, Tao Wu², and Ting Ma³

¹Electronics and Information Engineering, Harbin Institute of Technology at Shenzhen, Shenzhen, China, ²Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China, ³Harbin Institute of Technology at Shenzhen, Shenzhen, China

Whether clinical phenotype in Parkinson's disease (PD) is affected by cortical-basal ganglia motor circuit (CBG) dysfunction remains to be investigated. In this study, we utilized a high angular resolution diffusion imaging (HARDI) technique to investigate association between white matter structural connectivity within CBG and cognitive function related to PD. We found that the structural connectivity between the M1 cortical area and other regions within the CBG circuit decreased for those PD patients with severe cognitive symptoms, indicating that the less effective information processing between cortical and subcortical regions in CBG network could lead to cognitive deficits in PD patients.

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