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Abstract #2605

MRI Detection of Amyloid Related Imaging Abnormalities (ARIA) in a Non-Human Primate Model of Sporadic Cerebral Amyloid Angiography at 7-Tesla

Dina Ramadane1,2, Thomas Genovese1, Lori Hill3, Charles Kingsley4, Lawrence Williams3, Thomas Wisniewski1, Henrieta Scholtzova1, and Youssef Zaim Wadghiri1,2

1Department of Radiology, Bernard & Irene Schwartz Center for Biomedical Imaging & Center for Advanced Imaging Innovation & Research (CAI2R), New York, NY, United States, 2Preclinical Imaging Laboratory, Division of Advanced Research Technologies NYU Langone Health & NYU School of Medicine, New York, NY, United States, 3University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Here we describe a non-invasive brain imaging method studying the pathogenesis and long-term effects of ARIA (amyloid-related imaging abnormalities) in an aged squirrel monkey (Saimiri Boliviensis), a non-human primate model of naturally occurring cerebral amyloid angiopathy. We investigated both ARIA-E, characterized by vasogenic edema, and ARIA-H, characterized by MRI evidence of hemosiderin deposits as potential biomarkers to use in a MRI methodology to monitor newly developed AD treatments.

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