Abstract #2605

MRI Detection of Amyloid Related Imaging Abnormalities (ARIA) in a Non-Human Primate Model of Sporadic Cerebral Amyloid Angiography at 7-Tesla

Dina Ramadane^1,2, Thomas Genovese¹, Lori Hill³, Charles Kingsley⁴, Lawrence Williams³, Thomas Wisniewski¹, Henrieta Scholtzova¹, and Youssef Zaim Wadghiri^1,2

¹Department of Radiology, Bernard & Irene Schwartz Center for Biomedical Imaging & Center for Advanced Imaging Innovation & Research (CAI2R), New York, NY, United States, ²Preclinical Imaging Laboratory, Division of Advanced Research Technologies NYU Langone Health & NYU School of Medicine, New York, NY, United States, ³University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Here we describe a non-invasive brain imaging method studying the pathogenesis and long-term effects of ARIA (amyloid-related imaging abnormalities) in an aged squirrel monkey (Saimiri Boliviensis), a non-human primate model of naturally occurring cerebral amyloid angiopathy. We investigated both ARIA-E, characterized by vasogenic edema, and ARIA-H, characterized by MRI evidence of hemosiderin deposits as potential biomarkers to use in a MRI methodology to monitor newly developed AD treatments.

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