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Abstract #2606

Dynamics of white matter tract covariance across lifespan assessed with diffusion spectrum imaging

Yi-Xi Peng1, Chang-Le Chen2, Yung-Chin Hsu3, and Wen-Yih Isaac Tseng2,4,5

1Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 3Acroviz Technology, Inc., Taipei, Taiwan, 4Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 5Molecular Imaging Center, National Taiwan University College of Medicine, Taipei, Taiwan

In this study, we calculated tract covariance to describe the phenomenon of white matter differentiation and de-differentiation across lifespan, using diffusion spectrum imaging (DSI) and whole brain tract-based automatic analysis (TBAA) techniques. Differentiation was found to be highest in the 2nd decade and de-differentiation started to emerge at 3rd decade and peaked at 6th decade.

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