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Abstract #2607

Investigation of hypoxia after brain injury using a hypoxia-binding T1 contrast agent GdDO3NI

Babak Moghadas1, Vimala N Bharadwaj1, Sarah E. Stabenfeldt1, and Vikram D Kodibagkar1

1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States

In this study we have used the hypoxia-targeted MR contrast agent GdDO3NI, (a nitroimidazole-based T1 MRI contrast agent) to image the development of hypoxia in the rodent brain after traumatic brain injury (TBI). Our results indicate a statistically significant ~ 50% signal enhancement over baseline in the injury region using GdDO3NI compared to baseline values (~ 0%) observed with non-specific Gadoteridol (as control) at 3hours post injection. This study further demonstrates the utility of GdDO3NI in imaging tissue hypoxia and applicability to traumatic brain injury.

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